A Case of Acute Panmyelosis with Myelofibrosis / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
; : 207-211, 2004.
Article
in Ko
| WPRIM
| ID: wpr-71945
Responsible library:
WPRO
ABSTRACT
We experienced a case of acute panmyelosis with myelofibrosis, one of the acute myeloblastic leukemia (AML) subtypes according to WHO classification. A 44 year old man presented with a laborious dyspnea, dizziness, and generalized weakness. On admission, the peripheral blood revealed pancytopenia (hemoglobin 4.0 g/dL, WBC 2, 300/microliter, platelet 92, 000/microliter) with leukoerythroblastosis. The bone marrow (BM) aspirate yielded inadequate material but histological sections showed hyper-cellularity, proliferation of trilineage cell lines (panmyelosis) with extensive myelofibrosis, and clusters of immature cells at paratrabecular area. On ultrasonographic examination, no evidence of hepato-splenomegaly or any other abnormalities were noted. The follow-up BM study after the chemotherapy with Ara C for 7 days and idarubicin for 3 days showed no significant changes in pancytopenia and myelofibrosis but revealed a significant decrease in BM cellularity and blasts. We review and report the literature on acute panmyelosis with myelofibrosis.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pancytopenia
/
Blood Platelets
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Bone Marrow
/
Idarubicin
/
Leukemia, Myeloid, Acute
/
Cell Line
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Follow-Up Studies
/
Classification
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Dizziness
/
Drug Therapy
Type of study:
Observational_studies
/
Prognostic_studies
Language:
Ko
Journal:
The Korean Journal of Laboratory Medicine
Year:
2004
Type:
Article