Association between Expression of 8-OHdG and Cigarette Smoking in Non-small Cell Lung Cancer
Journal of Pathology and Translational Medicine
; : 217-224, 2019.
Article
in En
| WPRIM
| ID: wpr-766030
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Exposure to cigarette smoking (CS) is a major risk factor for the development of lung cancer. CS is known to cause oxidative DNA damage and mutation of tumor-related genes, and these factors are involved in carcinogenesis. 8-Hydroxydeoxyguanosine (8-OHdG) is considered to be a reliable biomarker for oxidative DNA damage. Increased levels of 8-OHdG are associated with a number of pathological conditions, including cancer. There are no reports on the expression of 8-OHdG by immunohistochemistry in non-small cell lung cancer (NSCLC). METHODS: We investigated the expression of 8-OHdG and p53 in 203 NSCLC tissues using immunohistochemistry and correlated it with clinicopathological features including smoking. RESULTS: The expression of 8-OHdG was observed in 83.3% of NSCLC. It was significantly correlated with a low T category, negative lymph node status, never-smoker, and longer overall survival (p < .05) by univariate analysis. But multivariate analysis revealed that 8-OHdG was not an independent prognostic factor for overall survival in NSCLC patients. The aberrant expression of p53 significantly correlated with smoking, male, squamous cell carcinoma, and Ki-67 positivity (p < .05). CONCLUSIONS: The expression of 8-OHdG was associated with good prognostic factors. It was positively correlated with never-smokers in NSCLC, suggesting that oxidative damage of DNA cannot be explained by smoking alone and may depend on complex control mechanisms.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Smoke
/
DNA Damage
/
DNA
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Smoking
/
Multivariate Analysis
/
Risk Factors
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Carcinoma, Non-Small-Cell Lung
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Tobacco Products
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
/
Male
Language:
En
Journal:
Journal of Pathology and Translational Medicine
Year:
2019
Type:
Article