American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
An. bras. dermatol
; 94(3): 355-357, May-June 2019. graf
Article
en En
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| ID: biblio-1011111
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BR1.1
ABSTRACT
Abstract Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acute pancreatitis, pancytopenia, and cardiogenic shock developed rapidly. Deficient renal clearance of meglumine antimoniate can result in severe toxicity, as observed in this case. These side effects are related to cumulative plasma levels of the drug. Therefore, second-line drugs like amphotericin B are a better choice for patients on dialysis.
Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Leishmaniasis Cutánea
/
Insuficiencia Renal Crónica
/
Antimoniato de Meglumina
/
Antiprotozoarios
Límite:
Adult
/
Humans
/
Male
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
An. bras. dermatol
Asunto de la revista:
DERMATOLOGIA
Año:
2019
Tipo del documento:
Article