Immune checkpoint inhibitor-induced endocrinopathies: a possible indicator of improved survival
Arch. endocrinol. metab. (Online)
; 67(6): e000654, Mar.-Apr. 2023. tab
Article
en En
|
LILACS-Express
| LILACS
| ID: biblio-1447274
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT Objective:
To evaluate the association between the patients' characteristics and the development of endocrine toxicity and to assess the association between endocrine-related adverse effects (ERAE) development and mortality. Subjects andmethods:
A retrospective observational study was conducted in 98 patients submitted to immunotherapy in our centre since its introduction in 2015 until March 2021. We excluded patients for which data regarding the corticotroph axis evaluation was missing. We used linear and logistic regression models to address our aims.Results:
We observed a significant negative association between ERAE development and death (OR 0.32; p = 0.028). We detected no associations between ERAE and the following characteristics age at immune checkpoint inhibitors (ICI) initiation, sex, diabetes mellitus, medical history, immunotherapy duration and ICI type.Conclusion:
The development of an ERAE may be associated with a better overall survival rate in advanced oncologic disease, supporting the role of an unleashed immune system response to malignant cells.
Texto completo:
1
Índice:
LILACS
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Idioma:
En
Revista:
Arch. endocrinol. metab. (Online)
Asunto de la revista:
ENDOCRINOLOGIA
/
METABOLISMO
Año:
2023
Tipo del documento:
Article