Imunogenicidade da proteína M recombinante de Streptococcus equi subsp. equi coadministrada com um adjuvante molecular / Immunogenicity of recombinant M protein of Streptococcus equi subsp. equi co administered with a molecular adjuvant
Arq. bras. med. vet. zootec. (Online)
; 69(5): 1351-1356, set.-out. 2017. tab, graf
Article
en Pt
| LILACS, VETINDEX
| ID: biblio-879374
Biblioteca responsable:
BR68.1
ABSTRACT
The strangles is an infectious disease that affects horses from all ages and causes important economic losses in the equine-related business. The aim of this work was to evaluate the immunogenicity of the recombinant M protein from Streptococcus equi (rSeM) co-administered with the recombinant heat-labile enterotoxin B subunit from Escherichia coli (rLTB) in mice and horses. A total of 72 female Balb-c mice were divided into eight groups and 18 horses were divided into six groups. The animals were inoculated by intramuscular (IM) or intranasal (IN) routes with different treatments of rSeM, rLTB and/or Al(OH)3. The results obtained in both species, independent of administration routes, demonstrated that rSeM + rLTB had higher levels of specific serum immunoglobulins, however, in mucosal immunity the increase was not identified. Thus, the use of rSeM as vaccine antigen and rLTB as adjuvant can be a potential tool in the control of equine strangles.(AU)
Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Proteínas de la Matriz Viral
/
Streptococcus equi
/
Enterotoxinas
/
Caballos
Límite:
Animals
Idioma:
Pt
Revista:
Arq. bras. med. vet. zootec. (Online)
Asunto de la revista:
Medicina Veterin ria
Año:
2017
Tipo del documento:
Article