L-ornithine-L-aspartate infusion efficacy in hepatic encephalopathy
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2008; 18 (11): 684-687
en En
| IMEMR
| ID: emr-87536
Biblioteca responsable:
EMRO
ABSTRACT
To determine the efficacy of L-ornithine-L-aspartate in treatment of hepatic encephalopathy. Randomized, placebo-controlled trial. Department of Gastroenterology and Hepatology, Sheikh Zayed Hospital, Lahore, from February to August 2005. Cirrhotic patients with hyperammonemia and overt hepatic encephalopathy were enrolled. Eighty patients were randomized to two treatment groups, L-ornithine-L-aspartate [20g/d] or placebo, both dissolved in 250mL of 5% dextrose water and infused intravenously for four hours a day for five consecutive days with 0.5 g/kg dietary protein intake at the end of daily treatment period. Outcome variables were postprandial blood ammonia and mental state grade. Adverse reactions and mortality were also determined. Both treatment groups were comparable regarding age, gender, etiology of cirrhosis, Child-Pugh class, mental state grade and blood ammonia at baseline. Although, improvement occurred in both groups, there was a greater improvement in L-ornithine-L-aspartate group with regard to both variables. Four patients in the placebo group and 2 in L-ornithine-L-aspartate group died. L-ornithine-L-aspartate infusions were found to be effective in cirrhotic patients with hepatic encephalopathy
Buscar en Google
Índice:
IMEMR
Asunto principal:
Encefalopatía Hepática
/
Cognición
/
Periodo Posprandial
/
Hiperamonemia
/
Dipéptidos
/
Amoníaco
/
Cirrosis Hepática
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
J. Coll. Physicians Surg. Pak.
Año:
2008