Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;32(2): 235-9, feb. 1999. ilus, tab, graf
Article
en En
| LILACS
| ID: lil-228266
Biblioteca responsable:
BR1.1
ABSTRACT
Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, does not synthesize sialic acid, but expresses a trans-sialidase (TS) that catalyzes the transfer of sialic acid from host glycoconjugates to the parasite surface. Here, we review studies that characterize the immune response to the catalytic domain of the enzyme in humans during Chagas' disease or in mice following immunization with the TS gene. In both cases, there are antibodies that strongly inhibit the enzymatic activity and generation of interferon-g-producing T cells
Texto completo:
1
Índice:
LILACS
Asunto principal:
Trypanosoma cruzi
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Enfermedad de Chagas
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Vacunas de ADN
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Neuraminidasa
Límite:
Animals
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Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Asunto de la revista:
BIOLOGIA
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MEDICINA
Año:
1999
Tipo del documento:
Article
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Congress and conference