Lepromatous leprosy patients produce antibodies that recognise non-bilayer lipid arrangements containing mycolic acids
Mem. Inst. Oswaldo Cruz
; 107(supl.1): 95-103, Dec. 2012. ilus, graf
Article
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| LILACS
| ID: lil-659747
Biblioteca responsable:
BR1.1
ABSTRACT
Non-bilayer phospholipid arrangements are three-dimensional structures that form when anionic phospholipids with an intermediate structure of the tubular hexagonal phase II are present in a bilayer of lipids. Antibodies that recognise these arrangements have been described in patients with antiphospholipid syndrome and/or systemic lupus erythematosus and in those with preeclampsia; these antibodies have also been documented in an experimental murine model of lupus, in which they are associated with immunopathology. Here, we demonstrate the presence of antibodies against non-bilayer phospholipid arrangements containing mycolic acids in the sera of lepromatous leprosy (LL) patients, but not those of healthy volunteers. The presence of antibodies that recognise these non-bilayer lipid arrangements may contribute to the hypergammaglobulinaemia observed in LL patients. We also found IgM and IgG anti-cardiolipin antibodies in 77% of the patients. This positive correlation between the anti-mycolic-non-bilayer arrangements and anti-cardiolipin antibodies suggests that both types of antibodies are produced by a common mechanism, as was demonstrated in the experimental murine model of lupus, in which there was a correlation between the anti-non-bilayer phospholipid arrangements and anti-cardiolipin antibodies. Antibodies to non-bilayer lipid arrangements may represent a previously unrecognised pathogenic mechanism in LL and the detection of these antibodies may be a tool for the early diagnosis of LL patients.
Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Autoanticuerpos
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Inmunoglobulina G
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Inmunoglobulina M
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Glucolípidos
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Lepra Lepromatosa
/
Membrana Dobles de Lípidos
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Ácidos Micólicos
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Antígenos Bacterianos
Tipo de estudio:
Prognostic_studies
/
Screening_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
2012
Tipo del documento:
Article