An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;46(7): 601-606, ago. 2013. graf
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| ID: lil-682395
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ABSTRACT
Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present study asked whether IL-33/ST2 signaling is relevant to overt pain-like behaviors in mice. Acetic acid and phenyl-p-benzoquinone induced significant writhing responses in wild-type (WT) mice; this overt nociceptive behavior was reduced in ST2-deficient mice. In an antigen-challenge model, ST2-deficient immunized mice had reduced induced flinch and licking overt pain-like behaviors. In the formalin test, ST2-deficient mice also presented reduced flinch and licking responses, compared with WT mice. Naive WT and ST2-deficient mice presented similar responses in the rota-rod, hot plate, and electronic von Frey tests, indicating no impairment of motor function or alteration in basal nociceptive responses. The results demonstrate that IL-33/ST2 signaling is important in the development of overt pain-like behaviors.
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Texto completo:
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Índice:
LILACS
Asunto principal:
Dimensión del Dolor
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Transducción de Señal
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Interleucinas
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Receptores de Interleucina
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Dolor Nociceptivo
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Hiperalgesia
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Asunto de la revista:
BIOLOGIA
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MEDICINA
Año:
2013
Tipo del documento:
Article