Characterization of reactive stroma in prostate cancer: involvement of growth factors, metalloproteinase matrix, sexual hormones receptors and prostatic stem cells
Int. braz. j. urol
; 41(5): 849-858, Sept.-Oct. 2015. tab, graf
Article
en En
| LILACS
| ID: lil-767051
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT Introduction and Objectives:
Reactive Stroma (RStr) is observed in many human cancers and is related to carcinogenesis. The objectives of the present study were to stablish a relationship of the RStr microenvironment with prostate cancer (Pca) through a morphological and molecular characterization, and to identify a possible relationship between RStr with worse prognosis factors and occurrence of malignant prostatic stem cells. Materials andMethods:
Forty prostatic samples were selected from men with Pca diagnosis submitted to radical prostatectomy; they were divided in two groups Group-1 (n=20) samples without reactive stroma; Group-2 (n=20) samples of PCa with intense stroma reaction. Prostatic samples were evaluated for RStr intensity by Masson Trichromic stain and posteriorly submitted to histopathological and immunohistochemistry analysis for antigens α-actin, vimentin, IGF-1, MMP-2, FGF-2, C-Myc, PSCA, AR, Erα and ERβ.Results:
Reactive stroma with intense desmoplastic reactivity was significantly more frequent in intermediate (Gleason 7, 3+4) and high grade tumors (Gleason 7, 4+3). The group with intense stromal reactivity showed significant higher levels of Vimentin, IGF-1, MMP-2, FGF-2, C-Myc, PSCA and ERα.Conclusions:
It can be concluded that RStr may be a predictive marker of Pca progression, since it was associated with increase of growth factors, imbalance of androgen and estrogen receptors and presence of malign prostatic stem cells.Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Neoplasias de la Próstata
/
Células Madre Neoplásicas
/
Adenocarcinoma
/
Células del Estroma
/
Células Epiteliales
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Aged80
/
Humans
/
Male
Idioma:
En
Revista:
Int. braz. j. urol
Asunto de la revista:
UROLOGIA
Año:
2015
Tipo del documento:
Article
/
Project document