Medication-related osteonecrosis of the jaw. Introduction of a new modified experimental model
Acta cir. bras
; Acta cir. bras;31(5): 308-313, May 2016. tab, graf
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BR1.1
ABSTRACT
ABSTRACT PURPOSE:
To evaluate a modified experimental model for medication-related osteonecrosis of the jaw (MRONJ) through the upper right central incisor extraction followed by intravenous bisphosphonate administration.METHODS:
Forty five rats underwent the upper right central incisor tooth extraction were divided in 2 groups Group I - experimental group, 30 rats received an intravenous administration protocol of zoledronic acid 35μg/kg into the tail vein every two weeks, totalizing four administrations, during eight weeks of administration, previously the extraction, and Group II - control group, 15 rats didn't received any medication before extraction. The groups were subdivided in postoperative periods 14/28/42 days. Clinical analysis and microtomography were performed to verify the presence of osteonecrosis. In addition, descritive histological analysis of hematoxylin-eosin stained sections was performed to evaluate the presence of osteonecrosis or necrotic foci.RESULTS:
Twelve (40%) rats, from experimental group, showed clinical signs of MRONJ (p=0.005), however, all samples showed imaginologic findings like osteolysis and loss of integrity of the cellular walls (p≤0.001). Microscopic evaluation revealed osteonecrosis areas with microbial colonies and inflammatory infiltrate (p≤0.001). In the control group, all animals presented the chronology of a normal wound healing.CONCLUSIONS:
The presence of medication-related osteonecrosis of the jaw after maxillary central incisor extraction in rats. This new experimental model may be considered an option for the study of MRONJ.Palabras clave
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Índice:
LILACS
Asunto principal:
Modelos Animales
/
Difosfonatos
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Osteonecrosis de los Maxilares Asociada a Difosfonatos
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Imidazoles
Tipo de estudio:
Guideline
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2016
Tipo del documento:
Article