Detection of rabies virus in different tissues of experimentally infected mice at preclinical and postclinical stages of the disease.
Indian J Exp Biol
; 1992 Oct; 30(10): 877-80
Article
en En
| IMSEAR
| ID: sea-57892
ABSTRACT
Rabies fixed virus (CVS) was passaged 10 times in mice by intramuscular (im) route followed by experimental inoculation of the titrated virus in 4 groups of mice with the dose of 0.1 ml of 1000 mouse (LD50 0.03 ml) using intracerebral (ic), intravenous (iv), intramuscular (im), intraocular (io), and intranasal (in) routes respectively. No marked variation in clinical signs due to variation of routes could be detected. Involvement of brain with io route could be detected even in preclinical stage. Although the virus could be detected in the postclinical stage in all the tissues under study (brain, skin, salivary gland and corneal impression), with io and ic routes spread of the virus was observed in comparatively higher concentrations.
Texto completo:
1
Índice:
IMSEAR
Asunto principal:
Rabia
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Virus de la Rabia
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Glándulas Salivales
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Piel
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Encéfalo
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Córnea
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Animales
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Ratones
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Antígenos Virales
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Indian J Exp Biol
Año:
1992
Tipo del documento:
Article