Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors.
Indian J Exp Biol
; 2005 Jul; 43(7): 614-9
Article
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| ID: sea-58781
Cyclooxygenase (COX-2) inhibitors were developed with the hope that they will cause fewer gastrointestinal adverse effects. Ability of selective as well as nonselective COX inhibitors to alter ischemia-reperfusion induced damage of gastric mucosa and hapten-induced colitis in rats has been compared. Celecoxib (10, 20 and 40 mg/kg(-l)) was significantly more potent at aggravating ischemia-reperfusion injury as compared to nimesulide. Similarly, celecoxib was found to maximally potentiate TNBS-induced colitis, followed by nimesulide and indomethacin. Celecoxib at its highest dose produced maximum deep histological injury. This paradoxic ulcer and colitis aggravating effect of selective COX-2 inhibitors may be explained by suppression of protective prostaglandins generated as a consequence of COX-2 induction in inflammatory states.
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Asunto principal:
Pirazoles
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Ratas
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Sulfonamidas
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Masculino
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Daño por Reperfusión
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Indometacina
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Inhibidores de la Ciclooxigenasa
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Ratas Wistar
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Colitis
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Tracto Gastrointestinal
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En
Revista:
Indian J Exp Biol
Año:
2005
Tipo del documento:
Article