Genetic analysis of two cases with MYC "negative" Burkitt lymphoma / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 1340-1344, 2023.
Article
en Zh
| WPRIM
| ID: wpr-1009300
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To carry out combined genetic analysis on two patients suspected for Burkitt lymphoma to facilitate their diagnosis and treatment.@*METHODS@#G banded karyotyping and interphase and metaphase fluorescence in situ hybridization (FISH) were used to detect the specific sites of chromosomes by using separate and fusion probes.@*RESULTS@#The separate probe showed no presence of MYC gene abnormality, while fusion probe confirmed the IGH::MYC translocation in the samples. Combined with the clinical features and pathological characteristics, the two patients were finally diagnosed with Burkitt lymphoma, which was confirmed by targeted capture next generation sequencing.@*CONCLUSION@#The separate probe for the MYC gene has some shortcomings and should be used together with dual fusion probe to improve the accuracy of diagnosis.
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Índice:
WPRIM
Asunto principal:
Translocación Genética
/
Genes myc
/
Linfoma de Burkitt
/
Hibridación Fluorescente in Situ
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Cariotipificación
Límite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2023
Tipo del documento:
Article