Pharmacokinetics and blood-brain barrier penetration of a novel salidroside derivative pOBz in rats / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 543-548, 2023.
Article
en Zh
| WPRIM
| ID: wpr-1013834
Biblioteca responsable:
WPRO
ABSTRACT
Aim To develop a ultra-high performance liquid chromatography electrospray-ionization tandem mass spectrometry ( UPLC-MS/MS ) method for the simultaneous determination of salidroside derivative pOBz in rat plasma and brain tissue, and to study the pharmacokinetic profile and penetration of the blood-brain barrier in rats after a single dose intravenous administration of pOBz. Methods SD rats were administered pOBz at a dose of 50 mg • kg
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WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Año:
2023
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Article