Homeostasis imbalance of metal ions in Alzheimer's disease / 中国药理学通报

ABSTRACT

Alzheimer's disease is an age-related neurodegenerative disease, and its pathogenesis has not been fully elucidated.In recent years the role of metal ions in the development and de-velopment of Alzheimer's disease has been brought into foeus.This paper reviews the homeostasis imbalance of metal ions, in- eluding the essential metal ions for human body such as Fe~ + / Fe3+ , CuV Cu2 + , Zn2 + , Mg2 + , as well as non-essential metal ions such as Al '+ and Hg"+ , involved in the pathogenesis of AI), aiming to provide research clues for anti-AD dnig targeting metal ions.