Progress of correlation of Epstein-Barr virus with acute lymphoblastic leukemia and chronic lymphoblastic leukemia / 白血病·淋巴瘤

ABSTRACT

Epstein-Barr virus (EBV) is a kind of virus commonly infected in human, most of which is latent infection, and only a few people develop malignant diseases. EBV is the pathogen of infectious mononucleosis (IM). EBV is associated with a variety of lymphatic and epithelial malignancies. Lymphatic system malignancies associated with EBV are mainly B-cell lineage lymphoma. Burkitt lymphoma (BL) and Hodgkin lymphoma (HL) are more studied, while acute lymphoblastic leukemia (ALL) and chronic lymphoblastic leukemia (CLL) are relatively less studied. This article reviews the biological structure, gene expression of EBV and its correlation with ALL and CLL.