Advances in CXCR3 and its ligand in pediatric cardiovascular disease / 国际儿科学杂志

ABSTRACT

Chemokine receptor 3(CXCR3), a sub chemokine of CXC, is mainly expressed on the surface of activated T cells, B cells and NK cells, and its specific chemokine ligands CXCL9, CXCL10, CXCL11, CXCL4 can induce targeted migration and immune response of target cells, which plays an important role in endothelial cell function, angiogenesis and inhibition.CXCR3 and its ligands have been found to be involved in the progression of cardiovascular diseases in children through various mechanisms including inflammatory chemotaxis, regulation of vascular function and inhibition of fibrosis.They are emerging important biomarkers for various cardiovascular diseases such as heart failure, Kawasaki disease, and hypertension, and are expected to become new targets for the treatment of cardiovascular diseases in children.This article reviews the functions and mechanisms of CXCR3 and its ligands in childhood cardiovascular diseases, in order to provide new ideas for drug development of childhood cardiovascular diseases.