Research progress on the roles of non-coding RNA in chemotherapy resistance of breast cancer / 实用肿瘤学杂志

ABSTRACT

Breast cancer is a kind of malignant tumor with high heterogeneity.Chemotherapy is one of the important treat-ments for advanced breast cancer or postoperative breast cancer.However,the emergence of secondary drug resistance weakens the ef-fectiveness of chemotherapy,leading to a poor prognosis for patients.In recent years,more and more studies have shown that non-coding RNA(ncRNA)can promote breast cancer chemotherapy resistance by regulating cell proliferation,tumor stem cell characteris-tics,epithelial-mesenchymal transition and other processes.This article reviews the research on the mechanism of ncRNA-mediated chemotherapy resistance in breast cancer.