Relationship among serum IL-8,Hcy,CRP levels,ventricular remodeling and prognosis in aged pa-tients with coronary heart failure and heart failure / 心血管康复医学杂志

ABSTRACT

Objective:To explore the relationship among serum levels of interleukin-8(IL-8),homocysteine(Hcy),Creactive protein(CRP),ventricular remodeling and prognosis in aged patients with coronary heart disease(CHD)and heart failure(HF).Methods:A total of 180 agedCHD+HF patients treated in our hospital were se-lected.Serum levels of IL-8,Hcy and CRP,and related indexes of left ventricular remodeling were measured.Pearson correlation analysis was used to analyze the correlation among serum IL-8,Hcy,CRP and ventricular re-modeling.All the included patients were given targeted cardiotonic therapy and followed up for six months.Accord-ing to presence of major adverse cardiovascular events(MACE)during follow-up,they were divided into poor prognosis group(n=45)and good prognosis group(n=135).The relationship among serum IL-8,Hcy,CRP lev-els and prognosis was analyzed.Results:As NYHA class increased,there were significant rise in serum levels of IL-8,Hcy and CRP,left ventricular posterior wall thickness(LVPWT),interventricular septal thickness(IVST)and left ventricular mass index(LVMI),and significant reductions in left ventricular end-diastolic diameter(LVEDd)and LVEF in aged CHD+HF patients,P＜0.05 or＜0.01;Pearson correlation analysis indicated that serum levels of IL-8,Hcy,CRP were significant inversely correlated with LVEDd and LVEF(r=-0.828～-0.770,P＜0.001 all),and significant positively correlated with LVPWT,IVST and LVMI(r=0.680～0.826,P＜0.001 all)in aged CHD+HF patients.Serum levels of IL-8,Hcy and CRP in poor prognosis group were signifi-cantly higher than those of good prognosis group,P=0.001 al.l ROC curve indicated that AUC of serum IL-8,Hcy,CRP and their combined detection was 0.761,0.792,0.810 and 0.916 respectively in predicting MACE during follow-up in these patients,and all possessed good predictive value,among which combined detection possessed the highest predictive value,P＜0.01 all.Conclusion:Serum levels of IL-8,Hcy and CRP significantly increase in aged CHD+HF patients,which are closely related to ventricular remodeling and poor prognosis,and their com-bined detection possesses good predictive value for poor prognosis.