Effect of trihalomethanes on germ cells and brood size of Caenorhabditis elegans / 安徽医科大学学报
Acta Universitatis Medicinalis Anhui
; (6): 5-9, 2023.
Article
en Zh
| WPRIM
| ID: wpr-1036367
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WPRO
ABSTRACT
Objective @#To investigate the effects of 3 types of trihalomethanes ( THMs) , the by⁃products in treatment of drinking water disinfection , on the development and reproductive capacity of germ cells of Caenorhabditis elegans. @*Methods @#Tribromomethane ( TBM) , trichloromethane ( TCM) and triiodomethane ( TIM) , 3 types of THMs were selected and wild type Caenorhabditis elegans was used as a model to detect germ cell apoptosis , oocyte number and the final brood size after exposure to different concentrations of THMs.@*Results @#The results of germ cell apoptosis showed that the exposure to 50 μmol/L TCM and TIM caused elevated levels of germ cell apoptosis in a dose⁃dependent manner. Oocyte counting results showed that exposure to 50 μmol/L all three THMs significantly reduced the number of oocytes. The brood size results showed that only 50 μmol/L TIM exposure significantly de⁃ creased the brood size of nematodes.@*Conclusion @#THMs showed negative impacts on the reproductive system of Caenorhabditis elegans , and the toxicity is related to the halogenated elements of THMs.
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Revista:
Acta Universitatis Medicinalis Anhui
Año:
2023
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Article