The similar characteristics of IgG4-related disease and allergic diseases / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 1936-1941, 2023.
Article
en Zh
| WPRIM
| ID: wpr-1046285
Biblioteca responsable:
WPRO
ABSTRACT
IgG4-related disease (IgG4-RD) is a chronic inflammation with fibrosis. About 30% to 40% of patients with IgG4-RD are complicated with atopic manifestations as allergic rhinitis and asthma, usually with elevated serum total immunoglobulin E and peripheral blood eosinophils, which are also of some value for predicting disease activity and relapse. Similar to allergic diseases, activation of type 2 inflammation is also observed in the pathogenesis of IgG4-RD, and eosinophils, basophils, mast cells, thymic stromal lymphopoietin, IL-33, IL-4, IL-5, and IL-13 all participate in the pathogenesis of IgG4-RD. Studies of susceptible genes showed that IgG4-RD and allergic disease shared the same susceptible genes. Monoclonal antibodies targeting type 2 inflammation pathway may become a novel choice for IgG4-RD treatment.
Texto completo:
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Índice:
WPRIM
Asunto principal:
Asma
/
Citocinas
/
Rinitis Alérgica
/
Enfermedad Relacionada con Inmunoglobulina G4
/
Inflamación
Límite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Preventive Medicine
Año:
2023
Tipo del documento:
Article