Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection / 소아과
Korean Journal of Pediatrics
; : 139-144, 2016.
Article
en En
| WPRIM
| ID: wpr-128882
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: Acute pyelonephritis (APN) is a serious bacterial infection that can cause renal scarring in children. Early identification of APN is critical to improve treatment outcomes. The neutrophil-lymphocyte ratio (NLR) is a prognostic marker of many diseases, but it has not yet been established in urinary tract infection (UTI). The aim of this study was to determine whether NLR is a useful marker to predict APN or vesicoureteral reflux (VUR). METHODS: We retrospectively evaluated 298 pediatric patients (age≤36 months) with febrile UTI from January 2010 to December 2014. Conventional infection markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and NLR were measured. RESULTS: WBC, CRP, ESR, and NLR were higher in APN than in lower UTI (P<0.001). Multiple logistic regression analyses showed that NLR was a predictive factor for positive dimercaptosuccinic acid (DMSA) defects (P<0.001). The area under the receiver operating characteristic (ROC) curve was high for NLR (P<0.001) as well as CRP (P<0.001) for prediction of DMSA defects. NLR showed the highest area under the ROC curve for diagnosis of VUR (P<0.001). CONCLUSION: NLR can be used as a diagnostic marker of APN with DMSA defect, showing better results than those of conventional markers for VUR prediction.
Palabras clave
Texto completo:
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Índice:
WPRIM
Asunto principal:
Pielonefritis
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Infecciones Bacterianas
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Sistema Urinario
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Infecciones Urinarias
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Reflujo Vesicoureteral
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Células Sanguíneas
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Proteína C-Reactiva
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Modelos Logísticos
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Estudios Retrospectivos
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Curva ROC
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Child
/
Humans
Idioma:
En
Revista:
Korean Journal of Pediatrics
Año:
2016
Tipo del documento:
Article