Alternative Polyadenylation in Human Diseases
Endocrinology and Metabolism
; : 413-421, 2017.
Article
en En
| WPRIM
| ID: wpr-149600
Biblioteca responsable:
WPRO
ABSTRACT
Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing. It is prevalent through all eukaryotes and has emerged as a key mechanism for controlling gene expression. Alternative polyadenylation (APA) plays an important role for cell growth, proliferation, and differentiation. In this review, we discuss the functions of APA related with various physiological conditions including cellular metabolism, mRNA processing, and protein diversity in a variety of disease models. We also discuss the molecular mechanisms underlying APA regulation, such as variations in the concentration of mRNA processing factors and RNA-binding proteins, as well as global transcriptome changes under cellular signaling pathway.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
ARN Mensajero
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Precursores del ARN
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Expresión Génica
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Proteínas de Unión al ARN
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Poliadenilación
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Eucariontes
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Serina-Treonina Quinasas TOR
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Transcriptoma
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Metabolismo
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Endocrinology and Metabolism
Año:
2017
Tipo del documento:
Article