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Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation
Article en En | WPRIM | ID: wpr-165942
Biblioteca responsable: WPRO
ABSTRACT
Heterotrimeric G proteins are key intracellular coordinators that receive signals from cells through activation of cognate G protein-coupled receptors (GPCRs). The details of their atomic interactions and structural mechanisms have been described by many biochemical and biophysical studies. Specifically, a framework for understanding conformational changes in the receptor upon ligand binding and associated G protein activation was provided by description of the crystal structure of the β2-adrenoceptor-Gs complex in 2011. This review focused on recent findings in the conformational dynamics of G proteins and GPCRs during activation processes.
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Texto completo: 1 Índice: WPRIM Asunto principal: Proteínas de Unión al GTP / Proteínas de Unión al GTP Heterotriméricas Idioma: En Revista: Biomolecules & Therapeutics Año: 2017 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Proteínas de Unión al GTP / Proteínas de Unión al GTP Heterotriméricas Idioma: En Revista: Biomolecules & Therapeutics Año: 2017 Tipo del documento: Article