Bone Mineral Density Changes after Orchiectomy using a Scrotal Approach in Rats
Korean Journal of Spine
; : 55-59, 2015.
Article
en En
| WPRIM
| ID: wpr-181090
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE: To investigate a suitable animal model for studies of male osteoporosis. Osteoporosis has a particularly high incidence in postmenopausal women, resulting in a substantial amount of research with respect to this disease in women. However, research on osteoporosis in men is still lacking. METHODS: Twenty 10-week-old male Sprague Dawley rats were used in this study, including 4 rats used to establish a baseline bone mineral density (BMD). The other 16 rats were divided into two groups: a sham surgery group (n=8), which underwent a sham operation, and an orchiectomized rat group (OCX) (n=8), which underwent bilateral OCX at 10 weeks of age. Bone mineral density was measured in 4 rats from both the sham surgery group and the OCX group 8 weeks after the surgery, while BMD in the remainder of the rats was measured 10 weeks post-surgery. RESULTS: Femoral BMD at 8 weeks post-surgery was found to be significantly lower in the OCX group compared to the sham group; a finding that was also similar 10 weeks post-surgery. CONCLUSION: 8 weeks after undergoing orchiectomy performed via a scrotal, white rats are a suitable model for studies of male osteoporosis.
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Texto completo:
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Índice:
WPRIM
Asunto principal:
Osteoporosis
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Orquiectomía
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Densidad Ósea
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Incidencia
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Ratas Sprague-Dawley
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Neoplasia Endocrina Múltiple Tipo 1
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Modelos Animales
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Fémur
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Korean Journal of Spine
Año:
2015
Tipo del documento:
Article