Modulation of Melanin Synthesis by Amaranthus spp. L Seed Extract in Melan-a Cells
Natural Product Sciences
; : 168-174, 2016.
Article
en En
| WPRIM
| ID: wpr-192322
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WPRO
ABSTRACT
Anti-melanogenic effects of amaranth (AT), one of the key source of squalene, were investigated in melanocytes. Amaranth seed powder was extracted with water and melan-a cells were treated with various concentrations of AT. By using HPLC, content of myo-inositol, one of potential active components, was measured in the crude extract of AT.AT reduced the melanin content in melan-a melanocytes and down-regulated melanogenic enzyme activity such as tyrosinase, TRP-1 and TRP-2. By regulating melanogenic enzyme activity, AT may be a potential natural source for whitening agent. Myo-inositol was detected in AT by HPLC and may be one of the active compounds from AT involved in the regulation of anti-melanogenesis. In this study, we demonstrated that AT has anti-melanogenesis properties. This new function of amaranth may be useful in the development of new skin-whitening products and its value as food.
Palabras clave
Texto completo:
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Índice:
WPRIM
Asunto principal:
Escualeno
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Agua
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Cromatografía Líquida de Alta Presión
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Monofenol Monooxigenasa
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Amaranthus
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Antígeno MART-1
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Melaninas
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Melanocitos
Idioma:
En
Revista:
Natural Product Sciences
Año:
2016
Tipo del documento:
Article