Incidence and Risk Factors for Leptomeningeal Carcinomatosis in Breast Cancer Patients with Parenchymal Brain Metastases
Journal of Korean Neurosurgical Society
; : 193-199, 2012.
Article
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| WPRIM
| ID: wpr-22526
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE:
The objective of study is to evaluate the incidence of leptomeningeal carcinomatosis (LMC) in breast cancer patients with parenchymal brain metastases (PBM) and clinical risk factors for the development of LMC.METHODS:
We retrospectively analyzed 27 patients who had undergone surgical resection (SR) and 156 patients with whole brain radiation therapy (WBRT) as an initial treatment for their PBM from breast cancer in our institution and compared the difference of incidence of LMC according to clinical factors. The diagnosis of LMC was made by cerebrospinal fluid cytology and/or magnetic resonance imaging.RESULTS:
A total of 27 patients (14%) in the study population developed LMC at a median of 6.0 months (range, 1.0-50). Ten of 27 patients (37%) developed LMC after SR, whereas 17 of 156 (11%) patients who received WBRT were diagnosed with LMC after the index procedure. The incidence of LMC was significantly higher in the SR group compared with the WBRT group and the hazard ratio was 2.95 (95% confidence interval; 1.33-6.54, p<0.01). Three additional factors were identified in the multivariableanalysis:
the younger age group (<40 years old), the progressing systemic disease showed significantly increased incidence of LMC, whereas the adjuvant chemotherapy reduce the incidence.CONCLUSION:
There is an increased risk of LMC after SR for PBM from breast cancer compared with WBRT. The young age (<40) and systemic burden of cancer in terms of progressing systemic disease without adjuvant chemotherapy could be additional risk factors for the development of LMC.Palabras clave
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Índice:
WPRIM
Asunto principal:
Encéfalo
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Mama
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Neoplasias de la Mama
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Espectroscopía de Resonancia Magnética
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Estreptotricinas
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Incidencia
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Estudios Retrospectivos
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Factores de Riesgo
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Quimioterapia Adyuvante
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Carcinomatosis Meníngea
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Journal of Korean Neurosurgical Society
Año:
2012
Tipo del documento:
Article