Application of HLAMatchmaker analysis eplets mismatch of renal transplant matching / 中国应用生理学杂志

ABSTRACT

<p><b>OBJECTIVE</b>Eplets mismatch based on HLAMatchmaker software evaluates the clinical application of kidney transplantation.</p><p><b>METHODS</b>In 239 cases of renal transplant,merits of methods of the traditional HLA six antigen matcheing criteria, cross reaction groups standard and Eplets mismatch based on HLAMatchmaker standard were compared respectively.</p><p><b>RESULTS</b>The number of mismatchs with three methods in 239 cases, were grouped according to low-high mismatchs. The results revealed that HLAMatchmaker algorithm could significantly increase the number of low mismatchs group 54 (22.6%), compared with the HIA group 19(7.9%) and CREGs group 32 (13.4%). The comparison was discovered statistical significance among the three groups (P<0.001), so the comparison between each group was.</p><p><b>CONCLUSION</b>HLAMachmaker of donor-recipients matching, is a more efficient, time-saving and high sensitivity matching solution to allograft renal transplantation.</p>