Pharmacokinetics interaction among three major active compounds of Shengmai formula in rats / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 6-12, 2012.
Article
en Zh
| WPRIM
| ID: wpr-247191
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the pharmacokinetic interaction among three major bioactive compounds of Shengmai formula.</p><p><b>METHODS</b>After oral administration of ginsenoside Rg(1), ginsenoside Rb(1) and schisandrin with the same dose(100 mg.kg(-1)) individually or in combination, rat serum samples were extracted, then these three compounds were determined by liquid chromatography-mass spectrometry(LC-MS). The pharmacokinetic parameters of three compounds in single or combination form were calculated by WinNonLinu6.0 using non-compartment model.</p><p><b>RESULTS</b>Compared with single drug group, the peak concentration of ginsenoside Rg(1) in combined group increased from(0.476 ±0.238) μg.ml(-1) to (1.946 ±1.432) μg.ml(-1), AUC(0-∞) increased from(0.523 ±0.238) μg.h.ml(-1) to (1.908 ±1.319) μg.h.ml(-1), CL decreased from(226311 ± 96819) ml.h(-1).kg(-1) to(90650 ±73684) ml.h(-1).kg(-1) and Vd decreased from(317110 ±154009) ml.kg(-1) to(130967 ±78306) ml.kg(-1). While the pharmacokinetic parameters of ginsenoside Rb(1) and schisandrin showed no significant change.</p><p><b>CONCLUSION</b>Combined oral administration of three compounds of Shengmai formula can improve the bioavailability of ginsenoside RgRg(1), however it does not change the pharmacokinetic behavior of ginsenoside RbRg(1) and schisandrin.</p>
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Índice:
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Asunto principal:
Compuestos Policíclicos
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Sangre
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Farmacocinética
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Disponibilidad Biológica
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Cromatografía Liquida
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Ratas Sprague-Dawley
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Lignanos
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Ciclooctanos
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Ginsenósidos
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Sinergismo Farmacológico
Límite:
Animals
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2012
Tipo del documento:
Article