Association of HMG-CoA reductase gene polymorphism with levels of lipids / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 207-210, 2003.
Article
en Zh
| WPRIM
| ID: wpr-248458
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the distribution of ScrF1 restriction polymorphism in intron 2 of the 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase gene in Chinese Han population and the association of the polymorphism with coronary heart disease(CHD).</p><p><b>METHODS</b>HMG-CoA reductase genotyping was performed using polymerase chain reaction-restriction fragment polymorphism.</p><p><b>RESULTS</b>HMG-CoA reductase allelic frequencies of A, a were 0.519, 0.481; 0.440, 0.560 in CHD group and control group respectively. There was no significant difference in frequencies of allele and genotype in ScrF1 polymorphism between CHD group and control group(P>0.05). However, the levels of plasma very low density lipoprotein (VLDL) and TG in CHD patients with AA genotype were higher than those in CHD patients with other genotypes(P<0.05). The frequencies of A, a alleles at ScrF1 polymorphic site were significantly different from those reported in European Caucasians (0.44 vs 0.55, 0.56 vs 0.45, P<0.05).</p><p><b>CONCLUSION</b>No direct association was found between the ScrF1 polymorphism and CHD, but there is a significant correlation between the AA genotype of the HMG-CoA reductase gene and the levels of plasma VLDL and TG in CHD group.</p>
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Índice:
WPRIM
Asunto principal:
Polimorfismo Genético
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Triglicéridos
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Sangre
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Análisis Químico de la Sangre
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VLDL-Colesterol
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Predisposición Genética a la Enfermedad
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Hidroximetilglutaril-CoA-Reductasas NADP-Dependientes
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Pueblo Asiatico
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Metabolismo de los Lípidos
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Genética
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2003
Tipo del documento:
Article