Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 453-456, 2016.
Article
en En
| WPRIM
| ID: wpr-258800
Biblioteca responsable:
WPRO
ABSTRACT
The use of exogenous carbon monoxide releasing molecules (CORMs) provides promise for clinical application; however, the hazard potential of CORMs in vivo remains poorly understood. The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to 400 μmol/L during 4-144 h post fertilization. Toxicity endpoints of mortality, spontaneous movement, heart rate, hatching rate, malformation, body length, and larval behavior were measured. CORM-3 disrupted the progression of zebrafish larval development at concentrations exceeding 50 μmol/L, resulting in embryonic developmental toxicity.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Compuestos Organometálicos
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Farmacología
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Pez Cebra
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Monóxido de Carbono
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Cardiotónicos
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Embriología
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Desarrollo Embrionario
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Relación Dosis-Respuesta a Droga
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Embrión no Mamífero
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Toxicidad
Límite:
Animals
Idioma:
En
Revista:
Biomedical and Environmental Sciences
Año:
2016
Tipo del documento:
Article