Long-term effect of high dose chemotherapy combined with stem cell transplantation on stage IV neuroblastoma in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 93-96, 2006.
Article
en Zh
| WPRIM
| ID: wpr-262776
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Neuroblastoma is a highly malignant tumor. Stage IV neuroblastoma has a very poor long-term outcome by conventional chemotherapy and surgery and better therapies are essential. This study aimed to explore the long-term effect of high dose induction chemotherapy combined with autologous peripheral blood stem cell transplantation and 13-cis retinoid acid treatment on stage IV neuroblastoma in children.</p><p><b>METHODS</b>Twenty-eight children with stage IV neuroblastoma, aged 2.1-11.5 years (mean 3.3 +/- 1.9 years), were employed for the study. Primary sites of the tumors included adrenal (n=23), chest (n=3), chest-abdomen (n=1) and sacrum (n=1). Before autologous peripheral blood stem cell transplantation the patients received 6 courses of intensive induction chemotherapy. During chemotherapy the autologous peripheral blood stem cells were harvested and the tumor excision was done. After transplantation the local radiation and 13-cis retinoid acid therapy were administered.</p><p><b>RESULTS</b>After 6 courses of induction chemotherapy 13 patients got complete remission (CR), 11 got partial remission (PR), and 4 had no response. The 24 patients who received CR or PR completed the full therapy. A 3.5 +/- 0.7 years follow-up showed that the 4-year event-free survival of the CR and PR patients was 29.2%. The median no-relapse survival time in CR patients was 4.1 +/- 0.7 years but 2.8 +/- 0.5 years in PR patients (t= 3.9, P < 0.01).</p><p><b>CONCLUSIONS</b>High dose chemotherapy combined with autologous peripheral stem cell transplantation and 13 cis-retinoid acid treatment can improve the long-term outcome of patients with stage IV neuroblastoma. The patients in CR before transplantation had better outcomes than those in PR.</p>
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Índice:
WPRIM
Asunto principal:
Patología
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Terapéutica
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Trasplante Autólogo
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Protocolos de Quimioterapia Combinada Antineoplásica
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Terapia Combinada
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Trasplante de Células Madre de Sangre Periférica
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Usos Terapéuticos
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Estadificación de Neoplasias
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Neuroblastoma
Límite:
Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2006
Tipo del documento:
Article