Study on chemical constituents from roots of Saussurea lappa / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the chemical constituents in roots of Saussurea lappa.</p><p><b>METHOD</b>Isolation and purification were carried out by silica gel, Sephadex LH-20 and RP-18 column chromatography. The chemical structures of constituents were elucidated on the basis of spectral data.</p><p><b>RESULT</b>Eleven compounds were isolated and identified as 5,7-dihydroxy-2-methylchromone (1), p-hydroxybenzaldehyde (2), 3,5-dimethoxy-4-hydroxy-benzaldehyde (3), 3,5-dimethoxy-4-hydroxy-acetophenone (4), ethyl 2-pyrrolidinone-5(s)-carboxylate (5), 5-hydroxymethyl-furaldehyde (6), palmitic acid (7), succinic acid (8), glucose (9), daucosterol (10), beta-sitosterol (11).</p><p><b>CONCLUSION</b>Compounds 1, 2, 4, 5, 7, 9 were isolated from the genus Saussurea for the first time.</p>