The Epidemiological Characteristics of Beijing Lineage Mycobacterium tuberculosis from a National Referral Center in China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 539-543, 2015.
Article
en En
| WPRIM
| ID: wpr-264549
Biblioteca responsable:
WPRO
ABSTRACT
Our study was to investigate the epidemiological characteristics of M.tuberculosis from a national tuberculosis referral center in China. All strains isolated from TB patients, were genotyped by the RD105 deletion, 8 and 51 SNP loci and VNTR. The high differentiation SNPs of modern Beijing strains were analyzed for protein function and structure. 413 M. tuberculosis were included. Of 379 Beijing lineage M. tuberculosis, 'modern' and 'ancient' strains respectively represented 85.5% (324/379) and 14.5% (55/379). Rv2494 (V48A) and Rv0245 (S103F) were confirmed as high differentiation SNPs associated with modern strains. In a word, Modern Beijing lineage M.tuberculosis was dominant and the structural models suggested that modern sub-lineage may more easily survive in 'extreme' host condition.
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Índice:
WPRIM
Asunto principal:
Filogenia
/
Tuberculosis
/
ADN Bacteriano
/
China
/
Epidemiología
/
Clasificación
/
Genoma Bacteriano
/
Epidemiología Molecular
/
Polimorfismo de Nucleótido Simple
/
Filogeografía
Tipo de estudio:
Prognostic_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Biomedical and Environmental Sciences
Año:
2015
Tipo del documento:
Article