Studies on in vivo release of berberine hydrochloride from carboxymethyl konjac glucomannan pellets in rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1591-1595, 2008.
Article
en Zh
| WPRIM
| ID: wpr-264888
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the absorption and concentration of berberine hydrochloride (BH) in gastric, entric, colonic tissue after intragastric administration of BH-containing carboxymethyl konjac glucomannan pellets for evaluating colon-specific drug delivery characteristics of the pellets.</p><p><b>METHOD</b>BH-containing carboxymethyl konjac glucomannan pellets (pellets group) and BH-containing carboxymethyl cellulose suspension (control group) were intragastric administrated to rats at the dose of 50 mg x kg(-1), respectively. A high performance liquid chromatography method determinated BH concentration in rat plasma and tissue. Drug delivery index (DDI) was calculated.</p><p><b>RESULT</b>The range of BH in plasma and tissue in rats were 0.025 2-2.52 mg x L(-1) (r = 0.999 2) and 0.126-25.22 mg x L(-1) (R > 0.99),respectively. The detection of BH in plasma and tissue were 10 microg x L(-1) and 8 microg x L(-1), respectively. The area under the curve (AUC(0 --> infinity)) in the plasma samples of pellets group was 0.477 times that of the control group; in the gastric, entric, colonic tissue, the AUC(0 --> infinity) of pellets group was as much as 0.187, 0.228, 2.00 times that of the control group, respectively. The DDI of the pellets was 0.392 4, 0.478 6, 4.193 in the gastric, entric, colonic tissue of the rat, respectively.</p><p><b>CONCLUSION</b>Carboxymethyl konjac glucomannan pellets may be a useful carrier of BH for colon-specific delivery.</p>
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Índice:
WPRIM
Asunto principal:
Especificidad de Órganos
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Berberina
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Calibración
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Farmacocinética
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Cromatografía Líquida de Alta Presión
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Sensibilidad y Especificidad
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Implantes de Medicamentos
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Absorción
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Intestinos
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Mananos
Tipo de estudio:
Diagnostic_studies
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Prognostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2008
Tipo del documento:
Article