Inhibitory effect of polysaccharides on the six-alpha-helix bundle formation of HIV gp41 protein / 南方医科大学学报
Journal of Southern Medical University
; (12): 1498-1500, 2007.
Article
en Zh
| WPRIM
| ID: wpr-283099
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the in vitro inhibitory effect of expolysaccharides from Streptomyces, polysaccharides of Ganoderma lucidum and rice bran on six-alpha-helix bundle formation of HIV gp41 protein.</p><p><b>METHODS</b>The amount of six-alpha-helix bundle formed in the presence of N36 and C34 was tested by ELISA in response to treatments with different doses of polysaccharides.</p><p><b>RESULTS</b>Expolysaccharides from Streptomyces potentially inhibited six-alpha-helix bundle formation with the effective concentration (IC(50)) of 145.48-/+7.25 mg /L. Polysaccharides of Ganoderma lucidum and rice bran showed no effect on the six-alpha-helix bundle formation.</p><p><b>CONCLUSION</b>Expolysaccharides from Streptomyces can inhibit the six-alpha-helix bundle formation of HIV gp41, whereas polysaccharides of Ganoderma lucidum and rice bran do not exhibit such activity.</p>
Texto completo:
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Índice:
WPRIM
Asunto principal:
Farmacología
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Polisacáridos
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Oryza
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Streptomyces
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Cinética
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Proteína gp41 de Envoltorio del VIH
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Química
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Estructura Secundaria de Proteína
/
Reishi
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2007
Tipo del documento:
Article