Effect of Chaihu Shugan Tang on excitability in different brain regions of pentylenetetrazole-kindled chronic epileptic rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1619-1622, 2010.
Article
en Zh
| WPRIM
| ID: wpr-285315
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of the Chinese compound prescription Chaihu Shugan Tang (CHSGT) on the excitability in the cerebral cortex and hippocampus (different brain regions) of pentetrazole (PTZ)-kindled chronic epileptic rats.</p><p><b>METHOD</b>To establish the model of chronic kindling rats intraperitoneal injected with pentylenetet. Fully kindled rats were randomized into control and experimental groups for intragastric administration of normal saline (control, model), Sodium Valproate and CHSGT at the high, medium and low doses for 4 consecutive weeks. The content of 2-NBDG, the glutamate (Glu) and the aspartate (Asp) in different brain regions of rats were detected by fluorescence imaging techniques and HPLC assay respectively.</p><p><b>RESULT</b>CHSGT at the high, medium and low doses all significantly decreased the content of 2-NBDG, the Glu and the Asp in different brain regions of chronic epileptic rats (P < 0.01).</p><p><b>CONCLUSION</b>CHSGT can inhibit the excitability in different brain regions of PTZ-induced epileptic rats, by decreasing the level of excitatory neurotransmitter maybe one of its antiepileptic mechanisms.</p>
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Asunto principal:
Pentilenotetrazol
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Terapéutica
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Encéfalo
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Medicamentos Herbarios Chinos
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Distribución Aleatoria
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Enfermedad Crónica
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Ácido Valproico
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Ácido Aspártico
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Ácido Glutámico
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Desoxiglucosa
Tipo de estudio:
Clinical_trials
Límite:
Animals
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Humans
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Male
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2010
Tipo del documento:
Article