Clinical significance of detecting t(11;14) by fluorescence in situ hybridization for the diagnosis of 7 patients with atypical mantle cell lymphoma / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 13-16, 2016.
Article
en Zh
| WPRIM
| ID: wpr-287960
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical features and diagnosis of 7 patients with atypical mantle cell lymphoma (MCL).</p><p><b>METHODS</b>The 7 MCL patients were misdiagnosed as chronic lymphocytic leukemia (CLL) due to a score of 4 for their immunophenotypes. The clinical features and diagnosis of such patients were retrospectively analyzed.</p><p><b>RESULTS</b>Six patients had superficial lymphadenectasis but their lymph nodes could not be palpated. All 7 patients were as stage IV considering bone marrow infiltration. Scores of immunophenotype of CLL were 4, and interphase fluorescence in situ hybridization (FISH) for t(11;14) were positive in all patients.</p><p><b>CONCLUSION</b>Some MCL patients have clinical features similar to CLL. Interphase FISH can play an important role in the diagnosis of MCL.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Translocación Genética
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Cromosomas Humanos Par 11
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Cromosomas Humanos Par 14
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Hibridación Fluorescente in Situ
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Linfoma de Células del Manto
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Diagnóstico
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Genética
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Métodos
Tipo de estudio:
Diagnostic_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2016
Tipo del documento:
Article