Study on optimization of formulation and preparation process of sinomenine liposomes / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 275-278, 2009.
Article
en Zh
| WPRIM
| ID: wpr-298418
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To optimize the formulation and preparation process of sinomenine liposomes.</p><p><b>METHOD</b>Method of aether injection and mixture uniform design were adopted to determine the formulation of sinomenine liposomes is the proportion of phospholipids, cholesterol and Vitamin E with the index of entrapment efficiency. And the single-factor test was used to study the preparation process of the liposomes, including the volume of buffer solution, the preparation temperature and the ultrasonic time.</p><p><b>RESULT</b>The optimized formulation was that the ratio of sinomenine : phospholipids : cholesterol : vitamin E mass ratio was 8.92 : 60.35 : 28.81 : 1.91. The volume of buffer solution was 50 mL x g(-1) membrane, the preparation temperature was 50 degrees C, and the ultrasonic time was 20 min.</p><p><b>CONCLUSION</b>Satisfactory shape and entrapment efficiency of the liposomes can be obtained by the optimized formulation and preparation process.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Tamaño de la Partícula
/
Fosfolípidos
/
Portadores de Fármacos
/
Farmacocinética
/
Química Farmacéutica
/
Colesterol
/
Tecnología Farmacéutica
/
Sistemas de Liberación de Medicamentos
/
Formas de Dosificación
/
Composición de Medicamentos
Tipo de estudio:
Health_economic_evaluation
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2009
Tipo del documento:
Article