Evaluation on in vitro release of Chinese medicinal compound sustained release preparations using multi-index chromatographic fingerprint / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 143-147, 2009.
Article
en Zh
| WPRIM
| ID: wpr-298447
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To establish a method to evaluate the in vitro release of Chinese medicinal compound sustained release preparations using multi-index chromatographic fingerprint.</p><p><b>METHOD</b>With the Chinese medicinal compound Jiangya sustained tablets as model preparation, the in vitro cumulative release of the main component flavones and fingerprint were determined by HPLC fingerprint. Aacacetin, rutin, luteolin, fingerprint were determined simultaneously and used to calculate the in vitro cumulative release of the tablets.</p><p><b>RESULT</b>Aacacetin, rutin, luteolin, and the fingerprint had different cumulative release.</p><p><b>CONCLUSION</b>Multi-index chromatographic fingerprint can reflect different content of multi components of preparations and can be used in the evaluation on in vitro release of the sustained release preparations of Chinese medicinal compound. The method is simple, rapid, and of multi information.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Factores de Tiempo
/
Medicamentos Herbarios Chinos
/
Cromatografía
/
Preparaciones de Acción Retardada
/
Metabolismo
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2009
Tipo del documento:
Article