Studies on self-microemulsifying drug preparations of total flavones of Hippophae rhamnoides / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To develop self-microemulsifying preparations of total flavones of Hippophae Rhamnoides L. (TFH) and the determination method of dissolution.</p><p><b>METHOD</b>The equilibrium solubility of TFH in different compositions of oils, emulsifier and assistant emulsifier was investigated. The self-microemulsion formula was optimized by constructing the pseudo-ternary phase diagrams of blank SMEDDS determining the self-microemulsifying efficiency and the stability of the SMEDDS. The 2 hours dissolution curve of TFH self-microemulsifying preparations was established. The optimal self-microemulsion formula was composed of MIGLYOL 812 N, Cremophor EL and 1,2-Propylene glycol.</p><p><b>RESULT</b>The ratio of them was 0.5:5.7:3.8. The average particle size was 12.1 nm. The dissolution rate at 10 minutes of TFH self-microemulsifying preparation was 131% higher than that of Xinda kang tablets.</p><p><b>CONCLUSION</b>The acquired microemulsion with small particle size is stable. The dissolution rate is evidently improved compared with market dosage forms.</p>