Efficacy of clonidine transdermal patch for treatment of Tourette's syndrome in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 537-539, 2009.
Article
en Zh
| WPRIM
| ID: wpr-304658
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Children with Tourette's syndrome (TS) have a poor treatment compliance due to side effects and inconvenient administration of oral drugs. This study explored the efficacy and safety of clonidine transdermal patch for treating TS in children.</p><p><b>METHODS</b>A total of 119 children with TS were randomly treated with the clonidine transdermal patch (n=65) or with oral haloperidol (n=54). The therapeutic efficacy was assessed based on the results of the Yale Global Tic Severity Scale (YGTSS) 4 weeks after treatment.</p><p><b>RESULTS</b>The clonidine transdermal patch group showed a higher reduction in the overall tic symptom scores (61.5+/-7.5%) than that in the haloperidol group (41.0+/-6.3%; p<0.05). Clonidine transdermal patch treatment was effective in 53 patients (81.5%) and 36 patients (67.5%) showed effective to oral haloperidol (p>0.05). Mild side effects (decrease of blood pressure and dizziness) were observed in 1 patient in the clonidine transdermal patch group. Mild hypermyotonia, drowsiness or lassitude as side effects occurred in 6 patients in the haloperidol group.</p><p><b>CONCLUSIONS</b>Clonidine transdermal patch is effective for the treatment of TS in children and its side effects are mild and rare.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Farmacología
/
Administración Cutánea
/
Síndrome de Tourette
/
Clonidina
/
Usos Terapéuticos
/
Quimioterapia
/
Haloperidol
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2009
Tipo del documento:
Article