Expression and significance of Survivin mRNA in lung cancer tissue microarray detected by FISH / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
; (4): 214-216, 2005.
Article
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| WPRIM
| ID: wpr-305418
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of Survivin mRNA in lung cancer tissue microarray (TMA) by fluorescence in situ hybridization (FISH) method, and determine the role and significance of it in lung cancer genesis and progress.</p><p><b>METHODS</b>The expression of Survivin mRNA was detected by FISH method and TMA technology. Fifty-four cases of lung cancer and 10 cases of normal lung tissue were examined.</p><p><b>RESULTS</b>Survivin mRNA was expressed in 66.7% (36/54) of lung cancer; the positive ratio of lung cancer was significantly higher than that of normal lung tissue (0/10; chi2 = 15.238, P < 0.05). The positive ratio of Survivin mRNA was significantly higher in poor differentiated cancer (20/24, 83.3%) than moderate and well differentiated cancer (16/30, 53.3%; chi2 = 5.40, P < 0.05). The positive ratio of Survivin mRNA was significantly higher in group with lymph node metastasis (27/32, 84.4%) than without lymph node metastasis (9/22, 40.9%; chi2 = 11.084, P < 0.05). The positive ratio of Survivin mRNA was significantly higher in stage III-IV(12/13, 92.3%) than stage I - II (24/41, 58.5%; chi2 = 5.066, P < 0.05).</p><p><b>CONCLUSION</b>Survivin mRNA highly expresses in lung cancer, which is related to the progress and malignant behavior. Survivin may play a promoting role in lung cancer genesis and progress and provide a basis for estimating prognosis and treatment.</p>
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Índice:
WPRIM
Asunto principal:
Patología
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ARN Mensajero
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Carcinoma de Células Escamosas
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Adenocarcinoma
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Regulación Neoplásica de la Expresión Génica
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Hibridación Fluorescente in Situ
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Análisis de Matrices Tisulares
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Proteínas Inhibidoras de la Apoptosis
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Genética
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Neoplasias Pulmonares
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Chinese Medical Sciences Journal
Año:
2005
Tipo del documento:
Article