Risk factors of premature rupture of membranes with neonatal infection: a single-center study / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To analyze the high-risk factors of premature rupture of membranes (PROM) with neonatal infection and explore their clinical significance.</p><p><b>METHODS</b>Forty-two cases of PROM with neonatal infections were retrospectively analyzed for the risk factors with another 42 PROM cases matched for gestational age without neonatal infections as the control group. The relations of gestational age, time from membrane rupture to delivery, mode of delivery, placental pathology, maternal serum C-reactive protein concentration, leukocyte and neutrophil values to neonatal infections were analyzed.</p><p><b>RESULTS</b>The time from membrane rupture to delivery was significantly longer and the incidence of chorioamnionitis significantly higher in the study group (P<0.05). Meningitis and neonatal sepsis occurred at a significantly higher incidence in preterm PROM group (P<0.05).</p><p><b>CONCLUSION</b>An appropriate extension of the gestation weeks and timely termination of pregnancy after dynamic monitoring of the biochemical changes and identification of the signs of infection are important to reduce the incidence of neonatal infection.</p>