Differential gene expressions in kidney Yang deficiency in individuals with sub-health status / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the gene expression profiles in kidney Yang deficiency in individuals with sub-health status.</p><p><b>METHODS</b>The subjects identified to have Kidney-yang deficiency and sub-health status were enrolled in this study with healthy subjects as the normal control. Using gene chip technique and MAS software, the gene expression profiles in kidney Yang deficiency in the subjects with sub-health status were analyzed.</p><p><b>RESULTS</b>Characteristic profiles of the differentially expressed genes were found between the kidney Yang deficiency group and normal control group. Among the total of 75 differentially expressed genes, 22 were up-regulated (with a ratio greater than 2) and 53 were down-regulated (with a ratio less than 0.5) in kidney Yang deficiency group.</p><p><b>CONCLUSION</b>Gene chip technique allows rapid and high-throughput screening for gene expression in kidney Yang deficiency and sub-health status, and a initial evidence of kidney Yang deficiency-related genes has been obtained.</p>