Mutation patterns in the RT region of hepatitis B virus P gene in patients treated with nucleoside/nucleotide analogs / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 342-345, 2009.
Article
en Zh
| WPRIM
| ID: wpr-310090
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze mutation patterns in the RT region of hepatitis B virus (HBV) P gene in patients treated with nucleoside or nucleotide analogs.</p><p><b>METHODS</b>Viral DNA was extracted from 227 serum samples of chronic hepatitis B patients from September, 2005 to March, 2007. The RT region of HBV P gene was PCR-amplified and sequenced.</p><p><b>RESULTS</b>Known resistant mutations were found in 111 cases (48.9%) among 227 samples, 75 cases with clear therapy history. Novel mutations, including A222T, L229V and S256C, were also found. The incidence of multi-drug resistance in patients sequentially treated with lamivudine and adefovir was 25% (4/16), and none of the patients treated with lamivudine plus adefovir in combination shown multi-drug resistance.</p><p><b>CONCLUSION</b>The patterns of mutation is complex in nucleotide analogue treated patients. Switching to adefovir in lamivudine resistant patients may lead to multi-drug resistance. Novel mutations identified in this study need further investigation.</p>
Texto completo:
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Índice:
WPRIM
Asunto principal:
Antivirales
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Farmacología
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Variación Genética
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Virología
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ADN Viral
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Análisis Mutacional de ADN
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Productos del Gen pol
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Virus de la Hepatitis B
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Inhibidores de la Transcriptasa Inversa
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Hepatitis B Crónica
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Hepatology
Año:
2009
Tipo del documento:
Article