Treatment preferences in men with erectile dysfunction: an open label study in Korean men switching from sildenafil citrate to tadalafil / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 760-770, 2007.
Article
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| WPRIM
| ID: wpr-310454
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>AIM</b>To evaluate patient preferences for sildenafil citrate or tadalafil (PDE-5 inhibitors available for the treatment of erectile dysfunction [ED]) and assess potential reasons for these preferences.</p><p><b>METHODS</b>This open-label study was conducted on Korean men taking sildenafil, at least 6 weeks prior to study entry, for ED. Following screening, patients continued sildenafil treatment for 4 weeks, then after a 1-week washout period, switched to tadalafil for 8 weeks. Patients then continued with their treatment of choice during an extension phase. Psychosocial factors (time concern, spontaneity, sexual self-confidence) were evaluated using Psychological and Interpersonal Relationship Scales (PAIRS), while timing of dose to sexual attempt patterns were assessed from patient diaries.</p><p><b>RESULTS</b>The present study enrolled 160 Korean men (mean age 55 years) with prior median sildenafil use of 585 days. During the extension phase, 73.7% of patients elected to take tadalafil, whereas 26.3% chose sildenafil (P < 0.001). After switching from sildenafil to tadalafil, mean PAIRS time concern scores decreased from 2.54 to 2.42 (P = 0.002), with no statistically significant differences observed between the sildenafil and tadalafil assessment phases in sexual spontaneity and self-confidence scores. Sexual attempts made > 4 h to =/< 36 h post-dose occurred in 4.5% of patients during the sildenafil assessment phase compared with 17.5% during the tadalafil assessment phase.</p><p><b>CONCLUSION</b>After experiencing both sildenafil and tadalafil, the majority of patients exhibited a preference for tadalafil. This preference might be influenced by psychosocial factors, such as decreased time concerns, and a broader window of opportunity available for sexual activity.</p>
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Índice:
WPRIM
Asunto principal:
Inhibidores de Fosfodiesterasa
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Piperazinas
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Psicología
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Purinas
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Sulfonas
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Carbolinas
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Resultado del Tratamiento
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Satisfacción del Paciente
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Usos Terapéuticos
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Relación Dosis-Respuesta a Droga
Límite:
Adult
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Aged
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Asian Journal of Andrology
Año:
2007
Tipo del documento:
Article