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Everted intestinal sac method for quick finding absorption ingredients of Wuzhuyu decoction / 中国中药杂志
Article en Zh | WPRIM | ID: wpr-328112
Biblioteca responsable: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To establish a method for quick finding the absorption ingredients of Wuzhuyu decoction in order to select the index to control its quality.</p><p><b>METHOD</b>The absorption of three concentration of Wuzhuyu decotion was investigated with the in vitro-everted intestinal sac model. The intestinal bag fluid of jejunum and ileum were collected in different time and the eight ingredients, which were evodiamine (Ev), rutaecarpine (Ru), limonin (Li), ginsenoside-Rb1, -Rg1, -Re (Rb1, Rg1, Re), isorhamnetin-3-O-beta-D-glucosyl(6''-->1'")-alpha-L-rhamnoside (Irs)and 6-gingerol (6-Gi), were detected by HPLC as the represent constituents in samples.</p><p><b>RESULT</b>Eight ingredients except Ru in samples could be detected, but Ev could not be detected in high concentration samples. The ratios between absorption ingredients were different from in Wuzhuyu decotion.</p><p><b>CONCLUSION</b>The in vitro-everted intestinal sac canc absorb the ingredients of Wuzhuyu decotion selectivity. Compare with the ileum, the jejunum can provide the more absorption information and faster, the best test time is 60-90 min.</p>
Asunto(s)
Texto completo: 1 Índice: WPRIM Asunto principal: Medicamentos Herbarios Chinos / Farmacocinética / Química / Ratas Wistar / Líquido Extracelular / Evaluación Preclínica de Medicamentos / Íleon / Absorción Intestinal / Yeyuno / Métodos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: Zh Revista: China Journal of Chinese Materia Medica Año: 2010 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Medicamentos Herbarios Chinos / Farmacocinética / Química / Ratas Wistar / Líquido Extracelular / Evaluación Preclínica de Medicamentos / Íleon / Absorción Intestinal / Yeyuno / Métodos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: Zh Revista: China Journal of Chinese Materia Medica Año: 2010 Tipo del documento: Article