Reversible Proximal Renal Tubular Dysfunction after One-Time Ifosfamide Exposure / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 244-246, 2010.
Article
en En
| WPRIM
| ID: wpr-33273
Biblioteca responsable:
WPRO
ABSTRACT
The alkylating agent ifosfamide is an anti-neoplastic used to treat various pediatric and adult malignancies. Its potential urologic toxicities include glomerulopathy, tubulopathy and hemorrhagic cystitis. This report describes a case of proximal renal tubular dysfunction and hemorrhagic cystitis in a 67-year-old male given ifosfamide for epitheloid sarcoma. He was also receiving an oral hypoglycemic agent for type 2 diabetes mellitus and had a baseline glomerular filtration rate of 51.5 mL/min/1.73 m2. Despite mesna prophylaxis, the patient experienced dysuria and gross hematuria after a single course of ifosfamide plus adriamycin. The abrupt renal impairment and serum/urine electrolyte imbalances that ensued were consistent with Fanconi's syndrome. However, normal renal function and electrolyte status were restored within 14 days, simply through supportive measures. A score of 8 by Naranjo adverse drug reaction probability scale indicated these complications were most likely treatment-related, although they developed without known predisposing factors. The currently undefined role of diabetic nephropathy in adult ifosfamide nephrotoxicity merits future investigation.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Sarcoma
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Doxorrubicina
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Mesna
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Cistitis
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Diabetes Mellitus Tipo 2
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Nefropatías Diabéticas
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Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos
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Disuria
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Síndrome de Fanconi
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Tasa de Filtración Glomerular
Límite:
Adult
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Aged
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Humans
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Male
Idioma:
En
Revista:
Cancer Research and Treatment
Año:
2010
Tipo del documento:
Article